The patient suffered from rheumatoid arthritis for several years, but then developed relapsing. Mitchinson fromaddenbrookes hospital, cambridge, andthe departmentojpathology, university ofcambridge synopsis apatient suffering from weberchristian panniculitis was found at necropsy to have similar lesions in the visceral adiposetissue. Professor of pathology, departments of dermatology, pathology, and surgery, university of oklahoma, and regional medical laboratory, tulsa, oklahoma, usa. Panniculitis refers to a broad spectrum of diseases that involve inflammation of the subcutaneous fat layer of the skin. It is a rare disease seen in females 3060 years of age. Weber christian disease is an eponym for a form of panniculitis, idiopathic nodular panniculitis, which is characterized by subcutaneous nodules, inflammatory cells in the fat lobules, and systemic symptoms. Weber christian syndrome a rare idiopathic condition that primarily affects adult females. Weberchristian disease synonyms, weberchristian disease pronunciation, weberchristian disease translation, english dictionary definition of weberchristian disease. Thevasculitis associated with weberchristian disease maybe explained as ahypersensitivity reaction. This recurring inflammation in the fat layer of the skin was. Weber christian disease synonyms, weber christian disease pronunciation, weber christian disease translation, english dictionary definition of weber christian disease. Articles on weberchristian disease in n eng j med, lancet, bmj. The thighs and lower legs are the most frequently affected areas. Media powerpoint slides on weber christian disease.
Weberchristian disease is an eponym for a form of panniculitis, idiopathic nodular panniculitis, which is characterized by subcutaneous nodules, inflammatory cells in the fat lobules, and systemic symptoms. Oct 07, 2019 panniculitis refers to a broad spectrum of diseases that involve inflammation of the subcutaneous fat layer of the skin. Panniculitis associated with pancreatic disease dermnet nz. It is a recurring inflammation of fatty layers of tissue present beneath the skin. General pathology lecture notes for health science students. Wyngaarden, jb, smith, lh eds cecil textbook of medicine. Weber christian panniculitis an overview sciencedirect.
Choose from used and new textbooks or get instant access with etextbooks and digital materials. We here report the rare case of a 64year old male patient, with pwcd. Weber christian disease or pfeifer weber christian disease or idiopathic relapsing febrile nodular nonsuppurative panniculitis was initially defined as a rare inflammatory disorder of unknown etiology affecting subcutaneous adipose tissue inter alia 1. Idiopathic lobular panniculitis is a condition in which inflammation occurs in the subcutaneous tissue, just beneath the skin. There was no apparent cause for the ocular pathology other than the preexistent panniculitis. Systemic weberchristian disease journal of clinical. Robbins pathologic basis of disease is the book to read, do not listen to anyone who will say otherwise. A patient suffering from weber christian panniculitis was found at necropsy to have similar lesions in the visceral adipose tissue. More than 60 years ago, christian described a panniculitis that. Weber christian disease is also referred to as idiopathic lobular panniculitis ilp and relapsing febrile nodular panniculitis syndrome.
Radiology 2 diagnostic pathology 33 diagnostic pathology 18 advances 2 the. David weedon ao md frcpa fcaphon, in weedons skin pathology third edition, 2010. The diagnosis and therapy of this rare type of panniculitis is still controversial and will be discussed in this article. Bone was designed for practicing pathologists who need access to uptodate, comprehensive, and concise bone pathology knowledge in one convenient place. Jun 20, 2017 robbins basic pathology pdf is the book of human pathology or clinical pathology. In severe instances, the inflammation can involve the liver, lungs, myocardium, spleen, kidneys, and adrenal glands. Taysachs disease an autosomal recessive lipid storage disorder caused by a deficiency of the enzyme hexosaminidase a which leads to an accumulation of gm2 ganglioside a fatty acid derivative in the ganglion cells of both the retina and the brain. Webers syndrome, also known as superior alternating hemiplegia, is a form of stroke characterized by the presence of an ipsilateral oculomotor nerve palsy and contralateral hemiparesis or hemiplegia. Assistant professor of medicine section of gastroenterology, department of medicine and pathology and laboratory medicine ebrc 515. We can find almost all data necessary in the clinical practice. British journal of dermatology and syphilis, oxford, 1925, 37. Weberchristian panniculitis and autoimmune disease. Weber christian disease wcd is an inflammatory disease of subcutaneous fat tissue which is characterized by relapsing, febrile tender nodules and histologically lobular panniculitis.
Also associated was the onset of diabetes mellitus, found at necropsy to be related to pancreatic islet amyloid deposition. Weberchristian disease, is a cutaneous condition characterized by recurrent subcutaneous nodules that heal with depression of the overlying skin. Medical research for weber christian disease including cure research, prevention research, diagnostic research, and basic research. A comprehensive textbook of lymphocytic infiltrates of the skin.
When the lesions occur internally, diagnosis during life is complicated by the difficulty of examining visceral adipose tissue and the disease may often go unrecognized, but patients suffering from weberchristian panniculitis should be investigated. Show less this new volume in the foundations in diagnostic pathology series packs all of todays most essential dermatopathology knowhow into a compact, highyield format. Weber graduated from the loyola university chicago stritch school of medicine in 2004. This expert volume in the diagnostic pathology series is an excellent pointofcare resource for practitioners at all levels of experience and training. Weberchristian disease radiology reference article. Weber is affiliated with university of chicago medicine. Nodular nonsuppurative panniculitis describes a rare group of skin disorders characterized by tender, painful bumps below the surface of the skin subcutaneous nodules that usually lead to inflammation of the subcutaneous layer of fat panniculitis. This writing could be useful as a reference book as for infectious diseases specialists, as for other specialists and even for medical students. This book is intended to be a textbook of general pathology for health science students. Weber works in chicago, il and 1 other location and specializes in pathology. Nk and nklike t cell lymphomas and weberchristian disease. We also call up on all those concerned to write a book on systemic pathology for health science students. Weberchristian disease is a rare inflammatory disease that affects the bodys fat tissues. Also called relapsing febrile nodular panniculitis.
Weberchristian disease is also referred to as idiopathic lobular panniculitis ilp and relapsing febrile nodular panniculitis syndrome the term weberchristian often refers to a. I am just copy pasting a part of my answer for another question here. The diagnosis of weberchristian disease has engendered more confusion in dermatopathology than practically any other. The second of a fourvolume set, this book covers oral cavity and oropharynx pathology. Weber s syndrome, also known as superior alternating hemiplegia, is a form of stroke characterized by the presence of an ipsilateral oculomotor nerve palsy and contralateral hemiparesis or hemiplegia. The term weber christian often refers to a group of diseases that involve the deep fat. Authored and updated by experts in the field, diagnostic. Kingscross hospital, dundee, scotland infectious disease and. These nodules tend to be 12 centimeters in length and most often affect the legs and feet. Weberchristian disease is also referred to as idiopathic lobular panniculitis ilp and relapsing febrile nodular panniculitis syndrome the term weber christian often refers to a group of diseases that involve the deep fat.
Weberchristian disease definition of weberchristian. So if you are a medical student and wants to learn pathology you should study this book. It may affect the whole body or any of its parts, and its etiology, pathology, and prognosis may be known or unknown. Weberchristian disease or pfeiferweberchristian disease or idiopathic relapsing febrile nodular nonsuppurative panniculitis was initially defined as a rare inflammatory disorder of unknown etiology affecting subcutaneous adipose tissue inter alia 1 however, the understanding of lobular panniculitis has expanded and cases that were once diagnosed in the water basket of weber. A patient with pfeiferweberchristian disease successful. Articles on weber christian disease in n eng j med, lancet, bmj.
This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. When the lesions occur internally, diagnosis during life is complicated by the difficulty of examining visceral adipose tissue and the disease may often go unrecognized, but patients suffering from weberchristian panniculitis should be investigated bearing. Elsevier is a leading publisher of health science books and journals, helping to advance medicine by delivering superior education. Ocular pathology associated weber christian syndrome. Weberchristian disease is an uncommon inflammatory disease of the fatty tissues of the body. General pathology covers the basic mechanisms of diseases whereas systemic pathology covers diseases as they occur in each organ system. Pfeiferweberchristian disease pwcd is a rare inflammatory disorder of the subcutaneous fatty tissue. Weberchristian disease wcd is an inflammatory disease of subcutaneous fat tissue which is characterized by relapsing, febrile tender nodules and histologically lobular panniculitis. A case is described of weberchristian panniculitis accompanied by a gammaglobulin disturbance which preceded by five years the diagnosis of an autoimmune hepatitis and pancytopenia. Weberchristian disease vaber krischen, relapsing febrile nodular nonsuppurative panniculitis of undetermined.
Weberchristian disease or pfeiferweberchristian disease or idiopathic. When the lesions occur internally, diagnosis during life is complicated by the difficulty of examining visceral adipose tissue and the disease may often go unrecognized, but patients suffering from weber christian panniculitis should be investigated bearing in. Its goal is to become a goto signout resource for head and neck pathology, available formats. This book is an excellent overwiew of clinial medicine, focused on the subject of infectious diseases. Clinical findings crops of subcutaneous nodules on the thighs, abdomen, arms and breasts, accompanied by fever, local inflammation, rheumatic complaints arthritis, arthralgia, myalgia, hepatosplenomegaly, abdominal pain and episcleritis. A case of relapsing nonsuppurative nodular panniculitis, showing phagocytosis of subcutaneous fatcells by macrophages.
Free pathology books download ebooks online textbooks. Pfeifer weber christian disease pwcd is a rare inflammatory disorder of subcutaneous adipose tissue. The topic weber christian disease you are seeking is a synonym, or alternative name, or is closely related to the medical condition idiopathic lobular panniculitis. We would also like to mention that the new curriculum for health officer students includes systemic pathology. Idiopathic lobular panniculitis is a condition in which inflammation. Elsevier is a leading publisher of health science books and journals, helping to advance medicine by delivering superior education, reference information and decision support tools to doctors, nurses, health practitioners and students. Skin inflammatory nontumor weber christian disease. A patient suffering from weberchristian panniculitis was found at necropsy to have similar lesions in the visceral adipose tissue. Its also known as relapsing febrile nodular panniculitis syndrome and idiopathic lobular panniculitis.
The topic pfeifferweberchristian disease you are seeking is a synonym, or alternative name, or is closely related to the medical condition idiopathic lobular panniculitis. And, expert consult functionality gives you easy access to the full text online as well as all of the book s images for enhanced visual guidance. Associate professor of pathology contact information. It includes the latest diagnostic information in this challenging subspecialty, while its unique image collection serves as an exceptional educational aid. Panniculitis and liver disease hepatic weber christian. David weedon ao md frcpa fcaphon, in weedons skin pathology third. Weber christian panniculitis an overview sciencedirect topics. Pfeiferweberchristian disease pwcd is a rare inflammatory disorder of subcutaneous adipose tissue. Mitchinson fromaddenbrookes hospital, cambridge, andthe departmentojpathology, university ofcambridge synopsis apatient suffering from weber christian panniculitis was found at necropsy to have similar lesions in the visceral adiposetissue. Disease definition of disease by medical dictionary.
The diagnosis of weberchristian disease has engendered more confusion in. Pdf weberchristian disease is characterized by recurrent inflammation in the fat layer of the skin. This page may contain content that is offensive or inappropriate for some readers. Weberchristian disease an overview sciencedirect topics. The prognosis of weberchristian disease may include the duration of weberchristian disease, chances of complications of weberchristian disease, probable outcomes, prospects for recovery, recovery period for weberchristian disease, survival rates, death rates, and other outcome possibilities in the overall prognosis of weberchristian. Weber christian disease, is a cutaneous condition characterized by recurrent subcutaneous nodules that heal with depression of the overlying skin it is a type of panniculitis.
Microbiology and pathology smith, alice lorraine on. Relapsing febrile nodular panniculitis, or weberchristian disease, is characterized by. Panniculitis associated with pancreatic cancer is more likely to ulcerate, persist and recur in comparison to lesions associated with inflammatory pancreatic disease. Weberchristian disease is a skin condition characterized by recurrent nodules under the skin that heal with depression of the overlying skin. Jan 27, 2010 pfeifer weber christian disease pwcd is a rare inflammatory disorder of the subcutaneous fatty tissue.
We studied 30 cases diagnosed as weberchristian panniculitis. Covering all areas of bone pathology, it incorporates the most recent clinical, pathological, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant. Oct 07, 2019 weber christian disease is rare in adults and even rarer in children. Weberchristian disease wcd is an inflammatory disease whose main histological feature is lobular panniculitis of adipose tissue. Common symptoms reported by people with weber christian disease.
Journal of the american academy of dermatology 393. Systemic weberchristian disease journal of clinical pathology. Weber christian disease is an uncommon inflammatory disease of the fatty tissues of the body. We want to help promote all of your pathology related books. Relapsing febrile nodular nonsuppurative panniculitis. It is caused by midbrain infarction as a result of occlusion of the paramedian branches of the posterior cerebral artery or of basilar. Cutaneous lesions associated with pancreatic cancer have also been reported to occur in areas other than the lower limbs including the thighs, abdomen, buttocks, arms, scalp and. Free pathology books download ebooks online textbooks tutorials. Medical research for weberchristian disease including cure research, prevention research, diagnostic research, and basic research. Enk ah, knop j 1998 treatment of relapsing idiopathic nodular panniculitis pfeiferweberchristian disease with mycophenolate mofetil. When the lesions occur internally, diagnosis during life is complicated by the difficulty of examining visceral adipose tissue and the disease may often go unrecognized, but patients suffering from weber christian panniculitis should be investigated.
University of dundee, scotland mbchb md equivalent graduate school. Its goal is to become a goto signout resource for head and neck pathology. Recurring tender erythematous subcutaneous nodules of legs and trunk, usually in women. Weberchristian disease implies systemic involvement when the skin lesions are accompanied by arthralgia, myalgias, and abdominal pain.
It is caused by midbrain infarction as a result of occlusion of the paramedian branches of the posterior cerebral artery or of basilar bifurcation perforating arteries. A case is described of weber christian disease associated with bilateral macular haemorrhages and retinal vascular abnormalities. As pathology deals with the diseases, this subject is a must for medical students. Robbins basic pathology pdf is the book of human pathology or clinical pathology. Weber christian disease is a rare inflammatory disease that affects the bodys fat tissues. Weber christian disease is a skin condition characterized by recurrent nodules under the skin that heal with depression of the overlying skin. It is also known as ideopathic relapsing febrile lobular nonsuppurative panniculitis and is characterized by recurrent subcutaneous inflammatory painful nodules, fever, and malaise due to systemic inflammation. The disorder appears on the skin as red or purple tender, raised lumps. The topic weberchristian disease you are seeking is a synonym, or alternative name, or is closely related to the medical condition idiopathic lobular panniculitis.
A case of weberchristian disease accompanied by a nasal. Whenthe lesions occurinternally, diagnosis duringlife. University of north carolina at chapel hill ma, public health health policy and administration, 1993 internships. Weberchristian disease is characterized by recurrent inflammation in the fat. Called also nodular nonsuppurative panniculitis and christianweber disease.
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